Milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate widen. Time points were selected in order to detect any early compatibility issues during medication contact times in multiport ysite component amount. Milrinone also works to vasodilate which helps alleviate increased pressures on the heart, thus improving its pumping action. Physical compatibility of milrinone lactate injection with intravenous. This lowers blood pressure and allows blood to flow more easily through ve. Oral and intravenous administration of toxic dosages of milrinone to rats and dogs resulted in myocardial degenerationfibrosis and endocardial hemorrhage, principally affecting the left ventricular papillary muscles. This medication is given by injection into a vein as directed by your doctor. Device indications for use contraindications midline catheters indicated for short or long term peripheral access to the peripheral venous system for selected intravenous therapies and blood sampling.
Reduce infusion rate in infants with renal impairment and prematurity. For blood therapy, it is recommended that a 4 french or larger catheter be used. Milrinone is an offwhite to tan crystalline compound with a molecular weight of 211. Milrinone is a member of the class of bipyridines that is 2pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid4yl, and methyl groups, respectively. Dilute contents of vial containing milrinone 10, 20, or 50 mg with 40, 80, or 200 ml, respectively, of 0. Intraarterial milrinone administration has been followed by milrinone continuous iv infusion for up to 14 days after initial bleeding. Critical care intravenous drug administration guide. Milrinone is usually given aroundtheclock for up to 48 hours. Feb 06, 2020 milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate widen. This lowers blood pressure and allows blood to flow more easily through your veins and arteries milrinone is used as a shortterm treatment for lifethreatening heart failure milrinone may also be used for purposes not listed in this medication guide. Physical compatibility of milrinone lactate injection with.
Anagrelide or cilostazol are agents that also inhibit phosphodiesterase iii and, in combination with milrinone, may increase the risk of adverse effects. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Intravenous compatibility chart acyclovir acyclovir. Ysite injection drug compatibility chart for critical care wards key to symbols. Milrinone, commonly known and marketed under the brand name primacor, is a medication used in patients who have heart failure. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. Check tubing below ysite carefully for discoloration, cloudiness or precipitation i incompatible do not mix blank do not mix. Dogs in normal anesthetized dogs, milrinone 30300 mgkg iv increases contractility by 40120% while decreasing diastolic blood pressure by 1030%. May 30, 2018 milrinone is an offwhite to tan crystalline compound with a molecular weight of 211. Indications and dose shortterm treatment of severe congestive heart failure unresponsive to conventional maintenance therapy not immediately after myocardial infarction, acute heart.
Mar 03, 2020 milrinone is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate widen. You will receive this injection in a clinic or hospital setting. Primacor injection should be given as a loading dose of 50 gkg administered over a period of 10 minutes usually followed by a continuous infusion at a dosage titrated between 0. Combinations were assessed for physical compatibility at baseline time 0, 5, 15, 30, 45, 60, 120, and 240 minutes. Research article pen access multiport ysite compatibility. You will initially receive this infusion in a clinic or hospital setting.
Milrinone morphine noradrenaline omeprazole thiopental vancomycin vasopressin arginine vasopressin rocuronium salbutamol sodium bicarbonate sodium chloride 0. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. May 04, 2019 according to the iv compatibility data in lexicomp and micromedex, which are both powered by trissels, alprostadil and furosemide are compatible for iv ysite administration 8,9. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Read all of this leaflet carefully before you start. Compatibility studies with the diluents were conducted in non.
Intravenous compatibility chart drug information for the. Supraventricular arrhythmia 4% hypotension 3% anginachest pain 1% abnormal liver function test results. Has 20 times the inotropic potency of the parent compound. Milrinone lactate is supplied in 10 ml and 20 ml singledose vials containing 1 mgml. Phase ii combinations drug 1 drug 2 drug 3 drug 4 drug 5 results furosemide 10 mgml epinephrine 100 mcgml milrinone mcgml na na incompatible furosemide 10 mgml epinephrine 100 mcgml milrinone mcgml dexmedetomidine 4 mcgml na incompatible furosemide 10 mgml epinephrine. All meds mixed by pharmacy have a 24hr sterility expiration 9. The prescriber is responsible for the verification of indications and dosages listed in the manufacturers package insert for the individual drugs, from which most information for this dosing guide is obtained. Intravenous compatibility chart drug information for. Milrinone 1mgml solution for injectioninfusion summary. The study compared a lower concentration of alprostadil in a different vehicle 7. In patients receiving primacor in phase ii and iii clinical trials, ventricular arrhythmias were reported in 12. It is a phosphodiesterase 3 inhibitor that works to increase the hearts contractility and decrease pulmonary vascular resistance. Side effects of primacor iv milrinone, warnings, uses.
In the absence of compatibility studies, this medicinal product must not be. For blood therapy, it is recommended that a 4 french or. Check tubing below ysite carefully for discoloration, cloudiness or precipitation. Milrinone is given as a continuous infusion through a needle placed into a vein. Other drugs should not be mixed with milrinone lactate injection until further compatibility data are available. Request pdf on apr 1, 2002, michael a veltri and others published physical compatibility of milrinone lactate injection with intravenous drugs commonly used in the pediatric intensive care unit. Information in this booklet should be used as a guide only. The majority of experience with intravenous milrinone has been in.
According to the iv compatibility data in lexicomp and micromedex, which are both powered by trissels, alprostadil and furosemide are compatible for iv ysite administration 8,9. Webmd provides common contraindications for milrinone intravenous. Thames valley ysite intravenous drugs compatibility chart. Nov 09, 2018 milrinone is given as an injection through a needle placed into a vein. Milrinone may also be used for purposes not listed in. Milrinone compatibility data, however, are not available for all antibiotics.
Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. Intravenous administration of formulary medications. A patient must have a central line available to receive these. Investigations of physical compatibilities of commonly used. This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Ysite injection drug compatibility chart for critical. The ph of intravenous milrinone is adjusted to between 3. Your heart rate and blood pressure will be monitored intermittently by the home care nurse while you are being treated with milrinone.
Milrinone lactate injection is a sterile, clear, colourless to pale yellow solution. Incompatibilities are based on meeting any of the following criteria. Milrinone is used as a shortterm treatment for treat lifethreatening heart failure. Milrinone side effects, dosage, interactions drugs. Im iv adults 2040 mg, may repeat in 12 hr and by 20 mg every 12 hr until response is obtained, maintenance dose may be given every 612 hr. Milrinone lactate milrinone lactate dose, indications. Milrinone is a phosphodiesterase type3 inhibitor that exerts most effect on the myocardium. Trissels in iv compatibility micromedex from the site homepage, select the iv compatibility tab. Two rn signatures are required to verify that physician order is calculated within guidelines and that the infusion rate is accurate 8. It is used particularly intravenously, as the lactate for the shortterm management of severe heart failure. Trissel, fashp, 2010, american society of healthsystem pharmacists.
Guidelines for use of prostaglandin e1 infusion pge1. Premixed infusions are already diluted and ready to use. Monitor electrolytes, renal function, blood pressure. Drugs administered to patients receiving pn should be given through a separate iv site or catheter lumen. Dogs in normal anesthetized dogs, milrinone 30300 mgkg iv increases contractility by 40120%.
Have two iv sites to avoid interruption of pge infusion 6. Ysite injection drug compatibility chart for critical care wards a m io d a ro n e a. Milrinone is a positive inotrope and vasodilator that relaxes the muscles in blood vessels to help them dilate. Additive compatibility drugs in syringe compatibility. Milrinone injection should be given as a loading dose of 50. Primacor milrinone lactate is designated chemically as 1,6 dihydro2methyl6oxo3,4bipyridine5carbonitrile lactate and has the following structure. The objective of this study was to determine whether milrinone 0. Treatment of low cardiac output states and as an adjunct to inhaled nitric oxide in neonates with persistent pulmonary hypertension of the neonate 1. Investigations of physical compatibilities of commonly. Physical compatibility of milrinone with levofloxacin and. Milrinone is used as a shortterm treatment for lifethreatening heart failure.
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